NuFund Venture Group Highlights Eyegenex’s Innovative Breakthroughs in Ophthalmic Care
July 15, 2024- San Diego, CA – NuFund Venture Group (NuFund) is proud to highlight the remarkable success of Eyegenex, a pioneering company in its portfolio.
Founded by NuFund members Dr. Prasad Sunkara and Steve Gormican, Eyegenex is dedicated to developing innovative solutions for a range of eye conditions, and is pioneering drugs for glaucoma and diabetic retinopathy (DR) to prevent blindness. The patents relating to the above therapeutics were licensed by Eyegenex from Prof. Ram Nagaraj’s laboratory at University of Colorado Anschutz Medical Campus at University of Colorado Denver. Glaucoma is the leading cause of blindness and is often related to high intraocular pressure (IOP).There is no existing treatment for this disease except for lowering IOP as a prevention by eye drops and surgery. However, 10-15% of patients experience progressive visual loss despite lowering of optimal IOP.
Eyegenex unveiled its Vision Restoration Platform, designed to address a spectrum of vision impairments by targeting and repairing damaged retinal cells. This groundbreaking platform integrates advanced gene and peptide therapeutics offering new hope to patients suffering from previously untreatable conditions. These therapeutics have shown significant protection of visual loss in rodent models of glaucoma. Preliminary studies in Non-human primate studies suggest a significant expression of the gene throughout the retina upon intravitreal injection of the gene. Further NHP studies are ongoing.
Based on these promising studies, Eyegenex is conducting IND enabling studies to initiate phase 1/2 human trials in Australia and US in 2025 aiming to validate the safety and efficacy of its innovative treatments.
Diabetic Retinopathy (DR) is caused by damage to blood vessels in the retina of diabetic patients, leading to vision loss. Eyegenex’s DR therapeutics are in the early stages of preclinical studies.
“We are thrilled to see the progress and impact Eyegenex is making in the field of ophthalmology. Our mission has always been to bring hope and solutions to patients suffering from vision impairments, and the recent developments have brought us one step closer to that goal,” said Dr. Prasad Sunkara, co-founder and CEO of Eyegenex and past Chairman of Life Sciences at NuFund.
A significant milestone for Eyegenex is the completion of successful clinical trials for its flagship treatment targeting glaucoma. To further support its growing portfolio of treatments, Eyegenex has expanded its research and development collaboration with Prof. Ram Nagaraj (inventor of the technology) and his colleagues at University of Colorado, Denver and several contract research organizations (CRO). “Our collaboration with top academic institutions and strategic partners has been instrumental in our success. We are excited about the future and the potential of our innovative therapies to transform vision health worldwide,” added Steve Gormican, co-founder of Eyegenex and NuFund member.
A recent paper published in Nature Magazine highlights Eyegenex’s pioneering work and unique mechanism of action in developing novel therapies for eye conditions, particularly glaucoma. The study emphasizes the potential of Eyegenex’s peptide therapy in treating retinal diseases and underscores the significance of their innovative approach.
Dr. Prasad Sunkara, reflecting on the journey, noted, “Being both a NuFund member and a founder who received investment from NuFund creates a unique full-circle moment. It’s a testament to the supportive and forward-thinking environment that NuFund fosters for its members and portfolio companies alike.”
About EyeGenex
Eyegenex is a leading biotechnology company focused on developing innovative treatments for a range of eye conditions. Utilizing advanced gene and peptide therapy, Eyegenex aims to restore vision and enhance the lives of patients worldwide. For more information, visit https://eyegenex.com
About NuFund Venture Group
NuFund Venture Group represents a new wave of angel investors, pioneering a novel fund model focused on emerging technology leaders. NuFund was formerly known as Tech Coast Angels – San Diego (TCA-SD), and the organization is one of the largest, most active, and most successful early-stage investor groups over the past 20+ years. We continually strive to foster a culture that is friendly, innovative, engaging, rewarding, and fun for all stakeholders. For more information, please visit http://www.nufund.com
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